We are in a time of explosive technology throughout the world. All around us technology and innovations are rapidly impacting and changing in many ways the delivery of healthcare. This beginner's guide melds informatics and systems thinking by incorporating many aspects of information, technology, and innovations we encounter when engaging in the delivery of healthcare. It explores topics surrounding epidemiology, data visualization, working with budgets in a nursing unit, interprofessional work, and the disruptive innovations we are experiencing as we learn more about the impact post COVID-19. All of these lead to embracing technologies, including generative AI and ChatGPT, in our education and practice. Each chapter engages with exercises, questions, and videos to provide hands-on interactions.